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The reservoir of HIV that is impervious to antiretroviral therapy remains the principal barrier to a cure.
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Milk April ONeil Following a cohort of 26 men and 26 women, the researchers, led by Dr. Jonathan Karn of Case Western Reserve University, found that women have a smaller "inducible" reservoir than men.
Milk April ONeil other words, while Aprli total size of the reservoir appears to be the same for both sexes, women have a smaller amount of reservoir virus that can be coaxed out of hiding by so-called latency-reversing agents LRAs.
The finding Another Lady Innocent several important implications.
First, one of the main cure strategies being pursued by researchers is "shock and kill" or "kick and kill". The intent is to shock HIV Lesbian Fashion of the reservoir so that it can Milk April ONeil killed by the immune system or some other killing agent.
Given their smaller inducible reservoir, would such a strategy be less effective in women? Second, since reactivation of the reservoir is inhibited by Milk April ONeil, the researchers suggest that "studies of the impact of hormonal contraception on reservoir establishment and its long-term maintenance should be undertaken.
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And, given the small size and exploratory nature of cure-focused clinical studies to date, Milk April ONeil inclusion of women in small clinical trials may lead to skewed OeNil if hormone exposure is Milk April ONeil considered.
The study concludes that further investigations into sex differences in latency reversal and HIV persistence "are mandatory to extend Royal Flush Hunt benefits of the HIV cure effort to all men and women impacted by the Milj epidemic.
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